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Moreover, we found that colistin-induced depolarization is sensitive to cyclosporin A, a potent inhibitor of mitochondrial cyclophilin D (CyPD), one of the components of the mPTP, whose expression and function are required for the onset of the permeability transition 49

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The peptide works through different pathways, primarily promoting angiogenesis (new blood vessel formation), modulating growth factors, and supporting tissue regeneration

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